Health and Nutrition
Are Artificial Sweeteners Making You Hungrier?
Research links sucralose to increased appetite and potential weight gain despite its low-calorie promise
- Yitzhak Eitan
- פורסם ד' ניסן התשפ"ה

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Artificial sweeteners like sucralose are popular in low-calorie foods and diet drinks. However, research shows that these sweeteners may actually increase hunger and contribute to weight gain. These findings were recently published in a study conducted at the University of Southern California.
According to the study, sucralose, commonly found in sugar substitutes, may activate areas of the brain associated with appetite, thereby increasing the sensation of hunger rather than reducing it as expected. Participants who drank water sweetened with sucralose reported feeling about 20% hungrier compared to those who drank water with regular sugar.
Lead researcher Dr. Katie Page explained that when the brain detects a sweet taste but doesn’t receive the expected calories, it may sense a deficit and send signals that lead to increased food intake. Previous studies have also indicated that women and individuals with obesity may be particularly sensitive to artificial sweeteners.
Medical recommendations now emphasize moderate use of artificial sweeteners, especially for individuals with insulin resistance or diabetes. Dr. Page advises against relying on artificial sweeteners as a sugar substitute, and instead encourages reducing overall consumption of all sweeteners.
Experts warn that while artificial sweeteners like sucralose can help lower calorie intake, overuse may disrupt the brain’s ability to regulate appetite, potentially leading to weight gain.